BCL2 and cancer: How Bcl-2 is overexpressed in cancer cells is not fully understood; however, Bcl-2 overexpression is correlated with chromosomal deletions leading to loss of Bcl-2—targeting miRNAs such as miR-195, miR-24-2, and miR-365-2 [16,17]; gene amplification [18]; and hypermethylation of the BCL2 gene [19].