BRCA1 (breast cancer 1), one of the key players in the cell cycle checkpoint and homologous recombination (HR), interacts with the mRNA splicing factor BCLAF1. This BRCA1-BCLAF1 complex regulates mRNA splicing of DDR genes ATRIP, BACH1, and EXO1 in response to DNA damage, although AS of these genes were not detected in this study. The gene discussed is BCLAF1; the disease is cancer.