Even though we did not observe unambiguous platelet-monocyte co-localizations within the retrieved clots, it appears plausible that the interaction of immune cells with platelets (e.g., via cluster of differentiation 40 (CD40) and CD40 ligand or P-selectin (CD62-P) and P-selectin glycoprotein ligand 1) [27,39] and endothelial cells (e.g., via intercellular adhesion molecule 1 and lymphocyte function-associated antigen 1) [24] also plays a role in human AIS. Here, CD40LG is linked to androgen insensitivity syndrome.