IFNG and infection: However, prolonged MTB-induced TLR-2 signaling has been shown to downregulate immune responses through recruitment of Foxp3 T-regulatory cells to the site of infection [13], increased interleukin (IL)-10 production [14], reduced macrophage IFN-γ sensitivity [15], inhibition of MHC class II expression [16], together with antigen processing and presentation evading recognition by T-cells [10,12].