We found that AESN elevated PPARα and PGC-1α mRNA levels in HFD/ethanol-induced rats, and inhibited the decrease in ACC, FAS, and ChREBP mRNA levels (Figure 6), thereby improving hyerlipidemia (Table 1) and suppress HSCs activation and hepatic fibrosis. The gene discussed is PPARGC1A; the disease is Hepatic fibrosis.