Several other studies have verified the benefit of CTNNB1 and BRAFV600E in the differential diagnosis of sellar lesions and we support this statement, with the caveat that V600E mutations may also occur for example in sellar pilocytic astrocytomas, and thus supportive histology is also required [21, 29, 44]. The gene discussed is CTNNB1; the disease is pilocytic astrocytoma.