Notably, mutations in either TDP-43 or FUS can be found in ALS, but only wtTDP-43 pathology is observed in sporadic ALS 14; we find in the present study that pathological wtTDP-43, but not wtFUS, is associated with propagation-competent SOD1 misfolding. The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.