Testing this, we find that HMEC-1 cells express levels of HPSE equivalent to the HPSEhigh myeloma cells (Figure 7a) and that conditioned medium from the HMEC-1 cells contains shed Sdc1, which is abolished upon treatment with the HPSE inhibitor Roneparstat (Figure 7b). The gene discussed is SDC1; the disease is plasma cell myeloma.