Prior work using CAG myeloma cells as a model for tumor formation in vivo has revealed a strong correlation between tumor growth and expression of HPSE and Sdc1.4, 6, 8, 11, 15 To identify a potential link between these two effectors, we examined the effects of high HPSE expression on CAG adhesion and motility on FN or VCAM-1, two ligands enriched in the bone marrow that are recognized by VLA-4 integrin expressed by these cells. This evidence concerns the gene FN1 and neoplasm.