TTP binds and destabilizes the mRNAs encoding cytokines and proto-oncogenes such as c-MYC, tumor necrosis factor α (TNFα), granulocyte monocyte colony stimulating factor (GM-CSF), interleukin-2 (IL2), cyclooxygenase 2 (COX-2), vascular endothelial growth factor (VEGF), nuclear factor κB (NF-κB), and hypoxia-inducible factor 1a (HIF-1a), which has a significant effect on cell viability, indicating a possible role for TTP in angiogenesis and tumor growth12, 13, 14, 15, 16. This evidence concerns the gene PTGS2 and neoplasm.