SPINK5 and ichthyosis: Interestingly, it has been suggested that GATA3 (in the 10p14 region associated with hair shape) inhibits the expression of serine protease inhibitor Kazal type-5 (SPINK5), mutations of which cause Netherton syndrome, an autosomal recessive congenital ichthyosis characterized by so-called Bamboo hair, epidermal hyperplasia and an impaired epidermal barrier function51.