So far, the presence of a mixed immune response, which is M2-like by surface marker expression but competent to produce extensive amounts of inflammatory cytokines, has been reported to be tissue- or site-specific, as observed for M2 macrophages infiltrating adipose tissue in obesity [46], for macrophages in the intestinal lamina propria [47] and in animal model of lung-specific IL-10 overexpression [48]. Here, IL10 is linked to obesity due to melanocortin 4 receptor deficiency.