CLCN3 and Hyperglycemia: Considering the low viability rate of HT22 cells under high glucose in previous experiment, here, it was exciting to see how the blocking of ClC-3 upregulated NPPB sensitive endogenous anion channels along with a downregulation of ClC-3 itself to normal levels successfully and completely abolished the hyperglycemia induced hippocampal neuronal apoptosis.