Furthermore, patients with evident bone lesions had significantly higher concentrations of plasma MCP-1 compared to patients without the presence of any lytic lesion or severe osteopenia with compressive fractures on standard bone radiographs (median 110.3 pg/mL, range 32.1–299.5 pg/mL versus median 86.4 pg/mL, range 8.3–138.9 pg/mL; p = 0.01; Figure 4 and Table 2). Here, CCL2 is linked to Osteopenia.