In our model, which employs endogenous activation of the renin-angiotensin system due to renal artery stenosis (Warner et al., 2012; Wang et al., 2013; Cheng et al., 2009) we find that db/db mice are more susceptible to both renal and cardiovascular disease than WT mice, despite similar elevation in systolic blood pressure (Hartono et al., 2014). Here, REN is linked to cardiovascular disorder.