In addition to the increased risk of developing ischemic heart disease, patients with diabetes are prone to develop diabetic cardiomyopathy, characterized by cardiac hypertrophy, myocardial fibrosis, and diastolic dysfunction (Asbun & Villarreal, 2006) Although leptin-deficient db/db mice do not develop myocardial remodeling or cardiac dysfunction, they are more susceptible to Ang II mediated hypertrophy and dysfunction (Harrap et al., 1996). This evidence concerns the gene LEP and cardiac hypertrophy.