AGT and abdominal aortic aneurysm: Although endogenous angiotensin II production is likely responsible for the development of aortic lesions in mice with RAS, the dissections observed in the current study were observed primarily in the ascending and proximal descending aorta, whereas angiotensin II infused mice tend to develop abdominal aortic aneurysms (Baker et al., 1984; Qian & Montgomery, 2012; Clauser, 1998).