However, when we administered, prior to vaccination, an attenuated Salmonella typhimurium (ST) targeting Signal Transducer and Activator of Transcription 3 (STAT3), which is overexpressed in many cancers and induceswhich contributes to tumorderived immune suppression, prior to vaccination, we observed enhancement of the survivinspecific response resulting in significant control of the primary tumor, reduction in lung metastases, and extension in survival. The gene discussed is STAT3; the disease is cancer.