CRHR1 and Anxiety: Our results demonstrated that severe traumatic stress in early adolescent induced lasting effects on anxiety-like behavior and spatial memory damage, different alterations of CRFR1 expression, and CRFR1 mRNA and miR-34c expression in hypothalamus between adolescent and adult period, which suggested that the miR-34c expression in hypothalamus may be unique regulator of stress reaction and may play a role in vulnerability to PTSD following exposure to traumatic experience.