The postinjection images of rats to whom anti-IL-1β mAb-SPION was administered (Figure 1(f)) showed areas of negative enhancement (red arrow) in the regional zone of the brain lesion, in agreement with a significant decrease in T2 values by 21.5% in comparison to the preinjection image of epilepsy (P < 0.01; Figure 1(g)). This evidence concerns the gene IL1B and epilepsy.