SPARC and neoplasm: The uptake mechanism of Abraxane® in cells remains to be elucidated, yet, Desai et al. have proposed that Gp60 and SPARC work in combination [54] suggesting Abraxane® is transported across the endothelial barrier by binding to Gp60 and subsequent caveolae-mediated transcytosis into the tumour interstitium where SPARC enhances the uptake of Abraxane into tumour cells [54].