To investigate in human data the involvement of Wnt, p53, and Notch pathways in EMT induction, we used a publicly available gene expression dataset of human colon cancer samples from The Cancer Genome Atlas (TCGA) project (Muzny et al., 2012) and compared the activity scores of Notch, Wnt and p53 pathways in metastatic and non-metastatic samples. The gene discussed is TP53; the disease is malignant colon neoplasm.