Although deficiency in other inflammasome components, including ASC, caspase-1, and IL-18, also led to dysbiosis and exacerbated colitis, deficiency in NLRC4, NLRP10, NLRP12, and AIM2 had no impact on the susceptibility of WT mice to colitis upon cohousing (111). This evidence concerns the gene NLRP12 and colitis.