Lipoteichoic acid (LTA), a component of Gram-positive bacteria cell wall, has been found to be elevated in the CSF of patients suffering from meningitis, it can induce proMMP-9 expression via the sequential activation of TLR2/MyD88, c-Src, PDGFR, PI3K/Akt, ERK1/2, IKKa/b, and NF-κB, leading to the promotion of RBA-1 cell migration. The gene discussed is NFKB1; the disease is meningitis.