Similar findings were evident when the improvement in depression was estimated using % change in the Ham-D rating, with baseline trait anxiety (r = −0.42, P = 0.03), baseline plasma noradrenaline (r = −0.66, P = 0.001), and P-selectin (r = −0.53, P = 0.006) and change in plasma noradrenaline (r = 0.51, P = 0.01) being significant. Here, SELP is linked to major depressive disorder.