It has been widely known that mutations in the Shh pathway cause a number of pathologies involving both facial and brain-related phenotypes (holoprosencephaly, Greig Cephalopolysyndactyly, Gorlin syndrome; Ming et al., 1998; Pan et al., 2013; Chaudhary et al., 2015). The gene discussed is SHH; the disease is holoprosencephaly.