FTO and obesity due to melanocortin 4 receptor deficiency: Remarkably, the anterior insula and the IFG, together with the orbito-frontal cortex are part of a dopaminergic cortico-striatal circuit involved in inhibitory control, decision making, emotional regulation, motivation, and salience attribution (Tomasi et al., 2015), a finding of particular interest as the FTO obesity-associated SNPs correlate with emotional and uncontrolled eating (Cornelis et al., 2014).