SOD1 and juvenile idiopathic arthritis: Moreover, considering antioxidative CS effects and the presence of oxidative stress in JIA patients, the aim of the study was to determine the relation of CS and CS-846 with levels of the most important enzymes for detoxification of peroxides in living cells, that is, catalase, superoxide dismutase (SOD), and glutathione peroxidase (GPx) determined in the blood of patients with newly diagnosed JIA and in the same patients after therapy modifying inflammation.