Through a detailed examination of those IPA analyses, the following interesting results have emerged: 1) Common top ranked pathways: There are several canonical pathways that are commonly found, including G-protein coupled receptor signaling (GPCR), Gαi signaling, Thrombin signaling, cAMP-mediated signaling, CREB signaling in neurons, CXCR4 signaling, role of NFAT in cardiac hypertrophy and α-Adrenergic signaling. This evidence concerns the gene CREB1 and cardiac hypertrophy.