The liver diseases PSC, PBC and AIH are commonly associated with aberrant ductular regeneration and, consistent with this, we found increased Fn14 (TNFRSF12A) mRNA and protein levels and expression of Fn14 associated with CK19+ ductule‐like structures in end‐stage liver disease explants. The gene discussed is TNFRSF12A; the disease is primary biliary cholangitis.