TACSTD2 and posterior cortical atrophy: Three representative human benign samples (HPCa173N, 175N and 177N) from PCa patients who had largely benign biopsies (Supplementary Fig. 1a and Supplementary Table 1) were selected for purification of basal (Trop2+CD49fhi) and luminal (Trop2+CD49flo) fractions6 using fluorescence-activated cell sorting (FACS; Fig. 1a and Supplementary Fig. 1b).