MKI67 and cancer: One group of studies used pretreatment biopsies of patients undergoing radiation and androgen deprivation as part of the Radiation Therapy Oncology Group (RTOG) 92–02 trial, defining a cut-off of 11.3 % high Ki-67 staining as independently correlated with an increase risk in distant metastasis, cancer-specific death, and overall death [13, 14].