ZNF423 and neoplasm: Moreover, when we classified patients from the REpository for Molecular BRAin Neoplasia DaTa database into three groups according to ZNF423 expression on the basis of their fold change with respect to median expression, a Kaplan–Meyer analysis for progression-free survival confirmed that higher levels of ZNF423 correlate with a far better prognosis compared with mid or low levels (Fig. 4c, left panel), with high statistical significance between high- (f.c.>2) and low-expressing (f.c.<2) tumours (Mantel–Haenszel test, P=1.65218e−5).