The context effect of Zfp423 is consistent with accumulating evidence on the extreme heterogeneity that characterizes gliomas, with a growing number of TFs being shown to play critical roles but in highly selected cases, as in the instance of the six TFs that underlie transcriptomic changes uniquely in the mesenchymal subtype HGG26 or, even more strikingly, the FGFR-TACC oncogenic fusion that was identified in three patients from a large cohort of HGG patients64. This evidence concerns the gene ZNF423 and glioma.