DAL-1, which belongs to the protein 4.1 superfamily, was first isolated as an expressed fragment of the 4.1 gene by differential display analysis of primary adenocarcinomas of the lung by Tran et al. DAL-1 is expressed in various normal tissues; however, its expression is greatly reduced or lost in lung3, breast4, prostate5, and kidney6 cancers and in meningiomas7. The gene discussed is EPB41L3; the disease is cancer.