In agreement with a NRP1 role in VEGF-induced permeability, a heptapeptide that blocks VEGF binding to NRP1 (see Section 6.1.2) attenuates both neovascularisation and vascular permeability in a mouse model of diabetic retinopathy (Wang et al., 2015a). This evidence concerns the gene NRP1 and diabetic retinopathy.