Accordingly, VEGF is essential also for retinal vascular development (Haigh et al., 2003) and drives neoangiogenesis and/or macular oedema in eye pathologies such as PDR, neovascular AMD and BRVO (Nissen et al., 1998, Saint-Geniez and D'Amore, 2004, Mitry et al., 2013). This evidence concerns the gene VEGFA and macular retinal edema.