The hearts of Nrp1Y297A/Y297A mice also have fewer coronary arteries and capillaries, similar to Vegfa120/120 mice expressing VEGF120 only at the expense of the heparin/NRP1-binding VEGF isoforms; moreover, a small proportion of these Nrp1 mutants die perinatally, similar to Vegfa120/120 mice that are known to suffer from ischemic cardiomyopathy (Carmeliet et al., 1999, Fantin et al., 2014). The gene discussed is NRP1; the disease is ischemic cardiomyopathy.