NRP1 and central nervous system cancer: Even though NRP1 acts mainly as a SEMA3A receptor, and NRP2 as a SEMA3F receptor in neurons, NRP2 can compensate for NRP1 as a SEMA3A-receptor during glioma cell migration in vitro and in vomeronasal axon guidance in mouse embryos in vivo (Cariboni et al., 2011).