For instance, administration of candesartan cilexetil, a selective and high-affinity Angiotensin II receptor antagonist, reduced ER stress toxicity induced by rotenone in a rat model of PD as evidenced by inhibition of ATF4, CHOP, and p53 upregulated modulator of apoptosis (PUMA) (Wu et al., 2013). The gene discussed is ATF4; the disease is Parkinson disease.