As mentioned, specific ablation of XBP1 in the nervous system has been associated with an adaptive ER stress response in models of PD but also in models of ALS and HD (Hetz et al., 2009, Matus et al., 2009, Valdes et al., 2014, Vidal et al., 2012). This evidence concerns the gene XBP1 and amyotrophic lateral sclerosis.