Indeed IRE1, which is the fifth most commonly mutated kinase in human cancer, contributes to the development of GBM in experimental models (Auf et al., 2010, Chevet et al., 2015, Dejeans et al., 2012, Drogat et al., 2007, Jabouille et al., 2015, Pluquet et al., 2013). Here, ERN1 is linked to glioblastoma.