EIF2AK3 and glioblastoma: Indeed, the PERK pathway was implicated in the regulation of GBM cell metabolism (Hou et al., 2015) and response to treatment (Hamed et al., 2010, Yacoub et al., 2010), whereas the ATF6 pathway was recently reported to contribute to GBM resistance to radiotherapy (Dadey et al., 2015).