For instance, administration of candesartan cilexetil, a selective and high-affinity Angiotensin II receptor antagonist, reduced ER stress toxicity induced by rotenone in a rat model of PD as evidenced by inhibition of ATF4, CHOP, and p53 upregulated modulator of apoptosis (PUMA) (Wu et al., 2013). This evidence concerns the gene DDIT3 and Parkinson disease.