CD4 and asthma: To identify molecular drivers (and negative regulators) of CD4 T cell responses to allergens, we considered three separate analyses: (i) HDM-stimulated versus unstimulated CD4 T cell responses within HDM-sensitized asthmatics (Fig. 1d); (ii) the differential response to HDM in sensitized asthmatics versus non-sensitized controls (Fig. 3c); (iii) and the asthma-associated module (Fig. 4c).