α7 nAChRs in this brain region have been studied as a possible novel target for cognitive and executive-control disorders such as schizophrenia, Alzheimer's disease, attention-deficit hyperactivity disorder and addiction states (Pandya and Yakel, 2013, Poorthuis and Mansvelder, 2013, Wallace and Bertrand, 2013). Here, CHRNA7 is linked to early-onset autosomal dominant Alzheimer disease.