The negative correlation of HMGB1 serum levels with age at onset of the disease suggests a specific effect of the HMGB1 in PD pathogenesis; as, even though indirectly, earlier occurrence of the disease is associated with a more “specific” pathology leading to clinical symptoms (de la Fuente-Fernández et al., 2011). The gene discussed is HMGB1; the disease is Parkinson disease.