In-situ prebiomarkers such as VEGFA, VEGF-R2 or CA9, as well as circulating prebiomarkers such as VEGFA, VEGFR1, ICAM1, IL6, IL8 or circulating tumor cells count [6] were reported to predict bevacizumab benefit, but this predictive value was generally weak and rarely confirmed [5]. The gene discussed is VEGFA; the disease is neoplasm.