Similar to siRNA-mediated knockdown of Mcl-1, EU-5346 induced marked downregulation of Her2 and Hif-1α in SKBR3 BC cells followed by cell death, as evidenced by PARP cleavage (Fig. 3c) and inhibition of [3H]-thymidine uptake (Fig. 3d). The gene discussed is HIF1A; the disease is breast cancer.