We subsequently investigated other genes involved in the regulatory networks of Hpse and Ccr6 (see discussion) and found specific gene expression changes of Ccr7 (chemokine (C-C motif) receptor 7), Cxcr5 (chemokine (C-X-C motif) receptor 5), Cxcr1 (chemokine (C-X-C motif) receptor 1), and Hspg2 (perlecan, heparan sulfate proteoglycan 2) in CAST/EiJ mice after infection (Fig. 14). The gene discussed is CCR7; the disease is infection.