In agreement with the recent studies of cohorts from Oxford, England (Kitley et al., 2014), Japan and Brazil (Sato et al., 2014), analyses of our patient cohorts from Tianjin and Barrow revealed that some MOG-ab-positive patients presented with simultaneous optic neuritis as well as myelitis and appeared to have a monophasic disease course with relatively mild residual disability. This evidence concerns the gene MOG and optic neuritis.