The finding that CXCR4 expression was higher in sporadic hemangioblastomas is striking as in VHL-disease a germline mutation in VHL leads to a defect VHL protein which results in enhanced transcription of CXCR4, its ligand CXCL12 as well as VEGFA [8]. The gene discussed is CXCR4; the disease is hemangioblastoma.