SMAD4 and breast carcinoma: In addition, our genetic data pointed to the possible involvement of genetic variants within the studied genes NCOR1, RUNX1, SMAD4, TBX3, TTN, ATR, ARID1B and MAP3K1. The most significant association with breast cancer risk was identified by RUNX1_rs8130963, RUNX1_ rs17227210, TBX3_rs8853, TBX3_ rs1061651, TBX3_2242442, TTN_rs12463674, and ATR_rs2227928.