MAP3K1 and breast cancer: Additionally, the minor allele carriers of the SNPs rs6001376 in APOBEC3B and rs832583 in MAP3K1 had an increased risk of BC (OR 2.15, 95 % CI 1.16-4.00; OR and OR 3.37, 95 % CI 1.20-9.47, respectively) (Table 2).