Among these the main indicators of neural degeneration, including synaptic failure and cognitive decline [88] are the accumulation of phosphorylated tau protein, which form neurofibrillary tangles (NFT), and the overexpression of amyloid precursor protein (APP), which leads to the accumulation of Amiloid-β (Aβ) peptide in senile plaques,. Here, APP is linked to Mental deterioration.