MOG and Peripheral demyelination: As previously reported, the serum MOG Ab POS patients in our cohort were younger at presentation, had higher systemic inflammatory markers (ESR), higher CSF cell count, CSF protein, CSF IgG levels, higher lesion load on MRI and more often had relapses and minor neurological deficits at follow-up which suggests that MOG Ab associated demyelination is a more inflammatory CNS syndrome than MOG Ab negative demyelination [2–4, 12, 25].