We found that expression levels of some LOAD GWAS genes that were identified in early GWAS [3–8], including ABCA7, BIN1, CD33, CLU, CR1, and MS4A6E, are associated with clinical and/or neuropathological aspects of AD [15] but failed to identify strong expression quantitative trait loci (eQTLs) [15, 17]. This evidence concerns the gene CLU and Alzheimer disease.