Furthermore, based on our previous experiences with ICC in adult and pediatric thyroid series [1-2,20], we evaluated whether the application of the same immunopanel comprised of Hector Battifora mesothelial cell-1 (HBME-1) and Galectin-3 might avoid unnecessary surgery in these elderly patients frequently affected by co-morbidities and disease burden. The gene discussed is LGALS3; the disease is intrahepatic cholangiocarcinoma.