Despite the fact that several authors emphasized that none of the immunomarkers alone shows a diagnostic accuracy sufficient for being used as single antibody useful for the diagnosis of malignant thyroid neoplasms, the detailed evaluation of our ICC panel in FN/AUS enforced the malignant role of HBME-1 and Galectin-3 also separately. Here, LGALS3 is linked to intrahepatic cholangiocarcinoma.