We hypothesized that BQ chewing may induce tissue inflammation, leading to OSF and oral cancer via stimulation of ROS, EGF/EGFR, JAK, IL-1α and ADAM17 (also called TNF-α converting enzyme, TACE) to impair differentiation and cell cycle progression, as well as the production of 8-isoprostane and PGE2 production in oral keratinocytes. Here, EGF is linked to lip and oral cavity carcinoma.