Considering that the biological function of TSLP is mediated by TSLPR and caspase-8 activation could result in alternatively activated intrinsic apoptosis pathway [25], it is very likely that TSLP-induced apoptosis of colon cancer cells is largely dependent on the extrinsic apoptosis pathway, albeit involves both extrinsic and intrinsic pathway. This evidence concerns the gene CRLF2 and colonic neoplasm.