Considering that the biological function of TSLP is mediated by TSLPR and caspase-8 activation could result in alternatively activated intrinsic apoptosis pathway [25], it is very likely that TSLP-induced apoptosis of colon cancer cells is largely dependent on the extrinsic apoptosis pathway, albeit involves both extrinsic and intrinsic pathway. This evidence concerns the gene CRLF2 and malignant colon neoplasm.