TSLPR knockdown significantly impaired the ability of TSLP to promote cancer cell apoptosis, as significantly lower percentages of Annexin V+ apoptotic cells were detected in the cultures of cancer cells transfected with TSLPR siRNA than those with scramble siRNA after 48 h following TSLP treatment (100 ng/ml) (Figure S3A and Figure 3D). This evidence concerns the gene CRLF2 and cancer.