INS and neoplasm: rpS6 phosphorylation deficiency exerts a wide range of effects that include reduced cell size, increased proliferation rate, reduced insulin secretion from beta cells [15], tumor suppression in pancreata expressing Akttg or RasG12D (Fig 2C and [19]), and altered apoptotic response to proteotoxic and genotoxic stressors in fibroblasts (Fig 4).