TP63 and amyotrophic lateral sclerosis: In addition, expression analysis of p53 family members indicated that in ALS the P63 gene seems more likely to play a regulatory role as the TAp63 isoforms are strongly upregulated and localized in the nuclei of the fibers during the ALS pathology (Figures 1, 3, 4, 5, figure supplement 2, 3, 4, 7).