TP53 and amyotrophic lateral sclerosis: p53/p63/p73 proteins have been linked to cell death, differentiation, metabolism, ER stress induction and ROS defence, which have all been reported during ALS (Hart, 2006; Barber and Shaw, 2010; Aguirre et al., 2005; Nishitoh et al., 2008; Manfredi and Xu, 2005).